New Insights Into the Pharmacological Potential of Plant Flavonoids in the Catecholamine System

Journal of Pharmacological Sciences

Nobuyuki Yanagihara²  Susumu Ueno¹  Yumiko Toyohira²  Kojiro Takahashi²  Keita Takahashi²  Han Zhang³  Masato Tsutsui⁴ 

[1] Department of Occupational Toxicology, Institute of Industrial Ecological Sciences, University of Occupational and Environmental Health, Japan;Department of Pharmacology, School of Medicine, University of Occupational and Environmental Health, Japan;Research Center of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, China;Department of Pharmacology, Graduate School of Medicine, University of The Ryukyus, Japan

关键词: adrenal medulla;    catecholamine;    flavonoid;    membrane estrogen receptor;    tyrosine hydroxylase;   

DOI  :  10.1254/jphs.13R17CP

学科分类：药学

来源: Nihon Yakuri Gakkai Henshuubu / Japanese Pharmacological Society

【 摘 要 】

References(30)Cited-By(8)Flavonoids are biologically active polyphenolic compounds widely distributed in plants. Recent research has focused on high dietary intake of flavonoids because of their potential to reduce the risks of diseases such as cardiovascular diseases, diabetes, and cancers. We report here the effects of plant flavonoids on catecholamine signaling in cultured bovine adrenal medullary cells used as a model of central and peripheral sympathetic neurons. Daidzein (0.01 �? 1.0 μM), a soy isoflavone, stimulated 14C-catecholamine synthesis through plasma membrane estrogen receptors. Nobiletin (1.0 �? 100 μM), a citrus polymethoxy flavone, enhanced 14C-catecholamine synthesis through the phosphorylation of Ser19 and Ser40 of tyrosine hydroxylase, which was associated with 45Ca2+ influx and catecholamine secretion. Treatment with genistein (0.01 �? 10 μM), another isoflavone, but not daidzein, enhanced [3H]noradrenaline uptake by SK-N-SH cells, a human noradrenergic neuroblastoma cell line. Daidzein as well as nobiletin (�? 1.0 μM) inhibited catecholamine synthesis and secretion induced by acetylcholine, a physiological secretagogue. The present review shows that plant flavonoids have various pharmacological potentials on the catecholamine system in adrenal medullary cells, and probably also in sympathetic neurons.

【 授权许可】

Unknown