Severe osteonecrosis of the jaws in a compromised patient subjected to bisphosphonate therapy

Revista Cubana de Estomatología

Dreyer de Menezes, Juliana¹  Cherubini, Karen¹  Figueiredo, Maria Antonia¹  de Mello Rahde, Nicole¹  Gonçalves Salum, Fernanda¹ 

[1] Pontifical Catholic University of Rio Grande do Sul, Porto Alegre, RS, Brazil

关键词: osteonecrosis;    bisphosphonates;    bone remodeling;    jaw diseases;   

DOI  :  

学科分类：基础医学

来源: SciELO

【 摘 要 】

Bisphosphonate-related osteonecrosis of the jaws is characterized by alveolar bone exposure, especially after mucosal trauma or after surgical procedures, in patients who have previously received or who are currently receiving bisphosphonates without a history of radiation therapy in the maxillofacial region. The condition is refractory to treatment, and attempts at debridement are not completely effective in eradicating the necrotic bone. We report here a case of a severe osteonecrosis of the jaws in a 77-year-old male patient, who had been subjected to chemotherapy and treatment with zoledronic acid and corticosteroid. The patient also had comorbidities such as diabetes and periodontal disease, which might have contributed to the lesion development. Bisphosphonate-related osteonecrosis of the jaws has become a reality in dental clinical practice. Although palliative treatment aiming at controlling pain, infection and injury progression is indicated, the therapeutic strategy is still challenging. So far, the best approach available is prevention, based on oral care before, during, and after bisphosphonate therapy.

【 授权许可】

Unknown