Changes in Streptococcus pneumoniae Serotypes in the Nasopharynx of Japanese Children after Inoculation with a Heptavalent Pneumococcal Conjugate Vaccine

Japanese Journal of Infectious Diseases

Minoru Sugita²  Masaei Iida³  Yoshiko Anahara³  Seiko Inamura⁵  Akiko Ebata³  Yoshikazu Ishii⁷  Yoko Suzuki¹  Fumie Mizuno⁸  Akihito Wada⁴  Kazuhiro Tateda⁷  Kaori Takahata¹  Taichiro Tanaka²  Bin Chang⁴  Yuji Nishiwaki²  Masahiro Ueno⁶ 

[1] Department of Pediatrics, Tokyo Women's Medical University Medical Center East;Department of Environmental and Occupational Health, School of Medicine, Toho University;Department of Bacteriology, Ageo Medical Laboratories, Inc.;Department of Bacteriology I, National Institute of Infectious Diseases;Yashio Ekimae Internal Medicine and Pediatric Clinic;Department of Pediatrics, Hasuda Issinkai Hospital;Department of Microbiology and Infectious Diseases, School of Medicine, Toho University;Department of Otorhinolaryngology, Hasuda Issinkai Hospital

关键词: Streptococcus pneumoniae;    vaccine-type;    non vaccine-type;    heptavalent;    pneumococcal conjugate vaccine;   

DOI  :  10.7883/yoken.67.40

学科分类：传染病学

来源: National Institute of Infectious Diseases

【 摘 要 】

References(15)In this study, we prospectively investigated changes in Streptococcus pneumoniae serotypes among Japanese children after heptavalent pneumococcal conjugate vaccine (PCV7) inoculation. We acquired nasopharyngeal swabs from the children at each routine PCV7 inoculation and again at least 2 months after the last PCV7 inoculation. We defined 2 periods with regard to each culture: the inoculation period as “the period of pre- or incomplete vaccination” and post-inoculation as “the period of post- or completed vaccination.” The prevalence of vaccine-type (VT) pneumococci was significantly reduced from 9.5% in the inoculation-period cultures to 2.9% in the post-inoculation cultures (P < 0.01). There was no statistical difference in the prevalence of non-vaccine-type pneumococci between the inoculation-period and post-inoculation cultures (24.1% versus 23.4%). The protection of PCV7 against nasopharyngeal colonization was inferred from the decrease in VT carriage post-inoculation. The decrease in VT carriage may be conducive to reducing VT transmission within the study area.

【 授权许可】

Unknown