Interleukin-1β Administered Intracerebroventricularly Stimulates the Release of Noradrenaline in the Hypothalamic Paraventricular Nucleus via Prostaglandin in the Rat

Endocrine Journal

MARL HOTTA¹  ICHIJI WAKABAYASHI³  CHIAKI TSUMORI¹  TAMOTSU SHIBASAKI²  TOSHIHIRO IMAKI¹  NAOKO YAMAUCHI³  KAORI TAKEUCHI³  HIROSHI DEMURA¹ 

[1] Department of Medicine, Institute of Clinical Endocrinology, Tokyo Women's Medical College;Department of Physiology, Nippon Medical School;Department of Medicine, Nippon Medical School

关键词: Noradrenaline;    Paraventricular nucleus;    Microdialysis;    Interleukin;    Prostaglandin;   

DOI  :  10.1507/endocrj.45.127

学科分类：内分泌与代谢学

来源: Japan Endocrine Society

【 摘 要 】

References(30)Cited-By(4)We evaluated the effect of intracerebroventricular (icy) administration of interleukin (IL) -1β on the rectal temperature and the release of noradrenaline (NA) in the hypothalamic paraventricular nucleus (PVN) of the rat. IL-1β increased rectal temperature at doses ranging from 300pg to 300ng, whereas it, at doses ranging from 3ng to 300ng, significantly stimulated the release of NA in the PVN measured by intracerebral microdialysis. The stimulatory effect of IL-1β on the release of NA was blocked by the subcutaneous injection of indomethacin. These findings suggest that IL-1β stimulates the release of NA in the PVN via prostaglandin, and that the release of NA in the PVN is not necessarily related to the increase in body temperature.

【 授权许可】

Unknown