Effect of Tandospirone on Sleep Latency in Rats Placed on a Grid Suspended Over Water

Journal of Pharmacological Sciences

Kazuaki Shinomiya¹  Shin Tokunaga²  Asae Ohmori²  Chiaki Kamei²  Yoshiaki Utsu² 

[1] Department of Pharmaceutical Care and Health Sciences, Faculty of Pharmaceutical Sciences, Okayama University, Japan;Department of Medicinal Pharmacology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Japan

关键词: tandospirone;    sleep latency;    sleep disturbed model;    antianxiety;    5-HT1A receptor;   

DOI  :  10.1254/jphs.FP0070981

学科分类：药学

来源: Nihon Yakuri Gakkai Henshuubu / Japanese Pharmacological Society

【 摘 要 】

References(18)Cited-By(6)The present study was performed to examine the effect of tandospirone on sleep latency in a new insomnia animal model by placing rats on a grid suspended over water. For investigating the mechanism of tandospirone, the effect of tandospirone on sleep latency was also studied using rats that were depleted with neuronal serotonin (5-HT) after p-chlorophenylalanine administration. Tandospirone caused a shortening of sleep latency dose-dependently, and a significant effect was observed at 20 mg/kg, p.o. or more. A shortening of sleep latency was observed by administration of p-chlorophenylalanine (300 mg/kg, i.p.) for 2 days. On the other hand, tandospirone exerted no potentiating effect on the shortening of sleep latency induced by p-chlorophenylalanine. From these findings, a shortening of sleep latency induced by tandospirone may occur through the pre-synaptic 5-HT1A receptors in rats.

【 授权许可】

Unknown