Atypical Vimentin Expression in a Feline Salivary Gland Adenocarcinoma with Widespread Metastases

Journal of Veterinary Medical Science

Yasmine BENAL¹  Laura CAPLIER²  Jean-Jacques FONTAINE²  Christelle VOLMER²  Farasoa RAKOTOVAO² 

[1]Ecole Nationale Vétérinaire de Lyon

[2]Ecole Nationale Vétérinaire d'Alfort

关键词: adenocarcinoma;    epithelial-mesenchymal transition;    feline;    metastases;    vimentin;   

DOI  :  10.1292/jvms.001681

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

References(11)We report herein a feline salivary gland adenocarcinoma with widespread metastases to draining lymph nodes, liver and lung, as well as an unusual metastasis to the spleen. Histologically, the primary salivary gland tumor consisted of low columnar to polygonal epithelial cells forming tubules and trabeculae. The spleen was infiltrated with sheets of poorly differentiated large round cells. Interestingly, morphologic change in epithelial cells was accompanied with the acquisition of vimentin intermediate filaments, a feature particularly evident in the splenic metastasis. This study highlights the role of epithelial cell plasticity during carcinogenesis and metastasis.

【 授权许可】

Unknown