MMHD [(S,E)-2-Methyl-1-(2-methylthiazol-4-yl) hexa-1,5-dien-ol], a Novel Synthetic Compound Derived From Epothilone, Suppresses Nuclear Factor-κB–Mediated Cytokine Expression in Lipopolysaccharide-Stimulated BV-2 Microglia

Journal of Pharmacological Sciences

Byung-Wook Kim¹  Su-Ho Park²  Sushruta Koppula¹  Hyo-Won Lee²  Dong-Kug Choi¹  Na-Ra Jeon¹ 

[1] Department of Biotechnology, Konkuk University, Korea;Department of Chemistry, Chungbuk National University, Korea

关键词: microglia;    lipopolysaccharide;    nuclear factor-κB (NF-κB);    MMHD [(S;    E)-2-methyl-1-(2-methylthiazol-4-yl) hexa-1;    5-dien-ol];    neurodegenerative disease;   

DOI  :  10.1254/jphs.09239FP

学科分类：药学

来源: Nihon Yakuri Gakkai Henshuubu / Japanese Pharmacological Society

【 摘 要 】

References(45)Cited-By(12)The effects of MMHD [(S,E)-2-methyl-1-(2-methylthiazol-4-yl) hexa-1,5-dien-ol], a novel synthetic compound derived from epothilone, was investigated for its effects on the expression of proinflammatory mediators in lipopolysaccharide-stimulated BV-2 microglia. MMHD attenuated the expressions of inducible nitric oxide synthase and cyclooxygenase-2 mRNA and protein without affecting cell viability. Moreover, MMHD suppressed nuclear factor-κB (NF-κB) activation via the translocation of p65 into the nucleus. These results indicate that MMHD exerts anti-inflammatory properties by suppressing the transcription of proinflammatory cytokine genes through the NF-κB signaling pathway.

【 授权许可】

Unknown