Determination of Optimal Dose of Arginine Vasopressin in Hemorrhagic Shock in Dogs

Journal of Veterinary Medical Science

Hee-Myung PARK¹  Hye-Jung LEE³  Jong-Hyun YOO²  Chul PARK¹  Dae-Hyun HAHM³ 

[1] Department of Veterinary Internal Medicine, College of Veterinary Medicine, Konkuk University;BK21 Program of Integrative Network Systems for Veterinarians in Basic Science, Industrial Animals and Preventive Medicines, Konkuk University;Acupuncture & Meridian Science Research Center, Kyung-Hee University

关键词: hemorrhagic shock;    optimal dose;    vasopressin;   

DOI  :  10.1292/jvms.69.755

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

References(24)Cited-By(3)The hemodynamic effects of vasopressin of high/low doses on dogs were investigated using experimentally induced hemorrhagic shock model. Experimental groups were categorized according to administered doses of vasopressin (0.1, 0.4 and 1.6 IU/kg) and hemodynamic parameters were measured before and after the graded-dose administration of vasopressin. Administration of high- and middle-dose vasopressin (0.4 and 1.6 IU/kg) showed superior increase in blood pressure and systemic vascular resistance, compared with those of low-dose one (0.1 IU/kg). Results of systolic arterial pressure and mean arterial pressure in 1.6 IU/kg-administered group revealed lower efficacy than that in 0.4 IU/kg group in spite of administration of higher dose. This study demonstrates that 0.4 IU/kg of vasopressin can be used as the most effective dose for improving hemodynamic condition in the decompensatory phase of hemorrhagic shock in dogs.

【 授权许可】

Unknown