Hepatoprotective Effect of Taurine Against Oxidative Stress Due to Methotrexate in Rat | Science Publications

American Journal of Animal and Veterinary Sciences

P. Kermanizadeh¹  M. Taghizadiyeh¹  E. Issabeagloo¹ 

关键词: Methotrexate;    taurine;    hepatoprotective;    oxidative stress;    rats;   

DOI  :  10.3844/ajavsp.2011.187.192

学科分类：兽医学

来源: Science Publications

【 摘 要 】

Problem statement: Taurine, 2-aminoethanesulphonic acid is an essential amino acid. It is present at high concentrations in many tissues. It plays important roles in numerous physiological functions including conjugation with bile acids, modulation of calcium levels and maintenance of osmolarity, antioxidation and stabilization of membranes. Methotrexate (MTX), as the most disease modifying anti-rheumatic drug used for Rheumatoid Arthritis (RA), has been available for clinical use since 1951. The main scope of this study was to assessment of probable Hepatoprotective effect of taurine as it antioxidant action against oxidative stress due to methotrexate in rats. Approach: Eighty male Wistar rats, weighing 200

【 授权许可】

Unknown