Reciprocal Expression of mRNA for Inhibin βC and βA Subunits in Hepatocytes

Endocrine Journal

HEINRICH SCHREWE²  ITARU KOJIMA¹  YOU-QING ZHANG¹  HIROSHI SHIBATA¹ 

[1] Department of Cell Biology, Institute for Molecular and Cellular Regulation, Gunma University;Department of Developmental Biology, Max Planck Institute of Immunology

关键词: Activin;    Liver regeneration;    Hepatocyte;   

DOI  :  10.1507/endocrj.44.759

学科分类：内分泌与代谢学

来源: Japan Endocrine Society

【 摘 要 】

References(18)Cited-By(12)Messenger RNA expression of activin βC subunit in the liver was compared with that for βA subunit before and after 70% hepatectomy. mRNA for βC was abundantly expressed in the liver but decreased at 12h and later after 70% hepatectomy, whereas that for βA was increased 12h after the hepatectomy. We also compared the expression of mRNA for βA and βC in cultured rat hepatocytes. mRNA for βC subunit was abundantly expressed in the beginning of the culture but was reduced gradually after stimulation with epidermal growth factor. In contrast, mRNA for βA subunit was undetectable before stimulation and was increased 24 to 48h after stimulation with the mitogen. These results indicate that expression of mRNA for βC and βA is regulated differently. The role of activin C may be different from that of activin A in the liver.

【 授权许可】

Unknown