Electrophysiological Characterization of Nicotine-Induced Excitation of Dopaminergic Neurons in the Rat Substantia Nigra

Journal of Pharmacological Sciences

Masashi Sasa¹  Takahiro Seki²  Norio Sakai²  Hiroaki Matsubayashi²  Taku Amano² 

[1] Nagisa Hospital;Department of Molecular and Pharmacological Neuroscience, Graduate School of Biomedical Sciences, Hiroshima University

关键词: nicotine;    patch clamp;    dopamine;    substantia nigra;    Parkinson’s disease;   

DOI  :  10.1254/jphs.93.143

学科分类：药学

来源: Nihon Yakuri Gakkai Henshuubu / Japanese Pharmacological Society

【 摘 要 】

References(19)Cited-By(9)The electrophysiological characteristics of nicotine-induced excitation of dopaminergic neurons in the rat substantia nigra was investigated using the whole-cell patch clamp technique under the voltage-clamp mode. Nicotine (0.01 – 100 μM) induced inward currents corresponding to nicotine-induced depolarization with an increase in firing in a dose-dependent manner. This current was inhibited by dihydro-β-erythroidine, a selective antagonist for the α4β2 type neuronal nicotinic receptor. Nicotine directly acts on postsynaptic α4β2 type nicotinic receptors and induces inward currents, resulting in excitation of dopaminergic neurons in the substantia nigra and subsequent enhancement of dopamine release in the corpus striatum.

【 授权许可】

Unknown