Effect of Noni C on the carbon tetrachloride-induced hepatic damage in rats

Revista Cubana de Plantas Medicinales

Maceira Cubiles, María Acelia¹  Montero González, Teresita¹  Martínez Martín, Sara M¹  Pérez de Alejo, José Luis¹  Jiménez Martínez, María del Carmen¹ 

[1] Hospital Militar Central Dr. Luis Díaz Soto, La Habana, Cuba

关键词: Noni;    glutamic piruvic transaminase;    glutamic oxaloacetic transaminase;    rat;    carbon tetrachloride;    hepatic damage;    experimental model;   

DOI  :  

学科分类：药理学

来源: Editorial Ciencias Medicas

【 摘 要 】

Introduction: liver diseases are a serious health problem. The study of natural agents that can reduce the chemical substance-induced hepatic damage has aroused a particular interest. Objective: to evaluate the effect of Noni C on the carbon tetrachloride-induced hepatic damage in an experimental model developed in male Wistar rats. Methods: An experimental study was conducted in which the positive control was carbon tetrachloride at a dose of 0.3 mL/kg of weight, intraperitoneally administered for 3 days, and the negative control was saline solution. Four doses of Noni C(85, 130, 170 and 215 mg/kg of weight) were administered for 6 days, after treatment with the carbon tetrachloride. glutamic piruvic and glutamic oxaloacetic transaminase levels were determined, as well as hepatic lesions such as cell tumors, reactive hepatitis, steatosis and necrosis. Results: glutamic piruvic and glutamic oxaloacetic transaminases levels significantly decreased at doses of 85 and 170 mg/kg of Noni C, and no necrosis or steatosis was observed in the groups treated with 170 and 215 mg/kg doses. Conclusions: the carbon tetrachloride-induced hepatic damage diminished in the groups treated with Noni C.

【 授权许可】

CC BY-NC