Autologous bone marrow stem cells transplant to intervertebral disc

Revista Cubana de Ortopedia y Traumatología

Tabares Neyra, Horacio Inocencio¹  Díaz Quesada, Juan Miguel² 

[1] Centro de Investigaciones en Longevidad, Envejecimiento y Salud, La Habana, Cuba;Hospital General Docente Calixto García, La Habana, Cuba

关键词: stem cells;    transplant;    intervertebral disc degeneration;    tolerance;    adverse effects;   

DOI  :  

学科分类：生理学

来源: SciELO

【 摘 要 】

Introduction:stem cell transplant was performed in seven patients diagnosed with degenerative one intervertebral disc.Objective:evaluate the safety and tolerance of the procedure to transplanted cells.Methods:cells were extracted from the patient's own bone marrow. They were isolated by the Ficoll-Hypaque method and they were implemented in discs selected as grades II and III according to Pfirrmann classification resonance imaging. Graft outcomes were evaluated one year later.Results:no significant adverse events were recorded from the procedure or graft cells. By using the Oswestry index, clinical outcomes were evaluated as beneficial, as well as the possible improvement in images from magnetic resonance imaging before and a year later.Conclusion:these results show that stem cells derived from the patient's own bone marrow can be safely transplanted with excellent tolerance and no complications using the method described.

【 授权许可】

CC BY-NC