Stronger Suppression of Serum Testosterone and FSH Levels by a Synthetic Estrogen than by Castration or an LH-RH Agonist

Endocrine Journal

SATOSHI KITAHARA¹  TOSHIHIKO TSUJII¹  SATORU KAWAKAMI¹  YUKIO KAGEYAMA¹  KEN-ICHIRO YOSHIDA²  HIROYUKI OSHIMA¹  KAZUHIRO ISHIZAKA¹ 

[1] Department of Urology, Tokyo Medical and Dental University School of Medicine;Department of Urology, Dokkyo University School of Medicine

关键词: Prostate cancer;    Synthetic estrogen;    Testosterone;    FSH;    LH-RH agonist;    Castration;   

DOI  :  10.1507/endocrj.44.527

学科分类：内分泌与代谢学

来源: Japan Endocrine Society

【 摘 要 】

References(25)Cited-By(11)Serum levels of LH, FSH and testosterone (T) were measured by radioimmunoassays in 36 patients with advanced prostate cancer before and during androgen ablation therapies. Both leuprolide acetate (LH-RH agonist: LHRH-A) and diethylstilbestrol diphosphate (DES-DP) administration decreased serum LH significantly to an undetectable level (LHRH-A: P<0.01, DES-DP: P<0.05). LHRH-A and DES-DP diminished serum FSH to 20% of the pre-treatment level (P<0.005) and to an undetectable level (P<0.001), respectively. LHRH-A and DES-DP decreased serum T to the castration level and an undetectable level, respectively (P<0.001). Serum levels of the same 3 hormones before and after DES-DP administration were measured in 8 patients who received DES-DP after LHRH-A treatment or castration because of relapse of the disease. DES-DP lowered serum FSH further than LHRH-A to an undetectable level (P<0.005) and diminished T further than previous treatments to an undetectable level (P<0.05 vs. LHRH-A, P<0.01 vs. castration). These results suggest that 1) DES-DP is able to reduce T production from extra-testicular site(s), and achieve the minimal serum T level, and 2) this DES-DP action appears to be one off the mechanisms of the effectiveness of estrogen on refractory prostate cancer after castration or LHRH-A. In addition, basal (independent of LH-RH) FSH secretion in elderly men is about 20% of total FSH secretion and DES-DP inhibits the basal FSH secretion at the level of the pituitary.

【 授权许可】

Unknown