Effects of Hyperoxia on Brain Tissue Oxygen Tension in Non-Sedated, Non- Anesthetized Arctic Ground Squirrels: An Animal Model of Hyperoxic Stress | Science Publications

American Journal of Animal and Veterinary Sciences

L. Duffy¹  S. Wu¹  Y. Ma¹ 

关键词: Brain temperature;    ground squirrels;    brain tissue;    oxygen partial pressure;    respiratory frequency;    body mass;    temperature correction;    barometric pressure;    cannula implantation;    systemic oxygen;   

DOI  :  10.3844/ajavsp.2011.7.17

学科分类：兽医学

来源: Science Publications

【 摘 要 】

Arctic Ground Squirrels (AGS) are classic hibernators known for their tolerance to hypoxia.AGS have been studied as a model of hypoxia with potential as a medical research model. Problemstatement: Their unique resistance to the stressors of low oxygen led us to hypothesize that AGSmight also be adaptable to hyperoxia. Approach: This study examined the physiological patternassociated with hyperoxia in response to brain tissue oxygen partial pressure (P_tO₂), brain temperature(T_brain), global oxygen consumption (V_O2) and respiratory frequency (f_R) using non-sedated and nonanesthetizedArctic Ground Squirrels (AGS) and rats. Results: We found that 1) 100% inspiredoxygen (F_iO₂) increased the baseline values of brain P_tO₂ significantly in both summer euthermic AGS(24.4

【 授权许可】

Unknown