Immunoprophylactic Effects of Administering Honeybee (Apis melifera) Venom Spray against Salmonella Gallinarum in Broiler Chicks

Journal of Veterinary Medical Science

Jin-A LEE¹  Bock-Gie JUNG¹  Jin-Kyu PARK²  Pung-Mi HYUN²  Bong-Joo LEE¹  Guk-Hyun SUH¹  Seong-Beom PARK¹ 

[1] College of Veterinary Medicine, Chonnam National University, 300 Yongbong-dong, Buk-gu, Gwangju 500–757, Republic of Korea;Wissen Co., Ltd., #302 Business Building S9, Hanbat University, Dukmyung-dong, Yuseong-gu, Daejeon 305–719, Republic of Korea

关键词: honeybee venom;    immune enhancement;    Salmonella Gallinarum;   

DOI  :  10.1292/jvms.13-0045

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

References(31)Cited-By(3)Antibiotics continue to be used as growth promoters in the poultry industry. Honeybee (Apis melifera) venom (HBV) possesses a number of beneficial biological activities, particularly for regulating the immune system. The aim of the present study was to evaluate the immunoprophylactic effects of HBV against Salmonella Gallinarum in broiler chicks as an initial step towards developing eco-friendly alternatives to reduce antibiotic use. HBV was administered using a spray technique. HBV improved body weight gain, particularly in the presence of infection. Moreover, HBV enhanced antibody production activity against formalin-killed S. Gallinarum. The CD4+:CD8+ T lymphocyte ratio, relative mRNA expression levels of interleukin-18 and interferon-γ, and serum lysozyme activity also increased following HBV administration before the infection period as well as during infection. HBV reinforced bacterial clearance and increased survivability against S. Gallinarum. Corresponding pathological analyses demonstrated that the HBV-sprayed group displayed mild and less severe abnormal changes compared with those in the control group. It was presumed that the prophylactic effects of HBV against S. Gallinarum were associated with its non-specific immune response stimulating activity. Thus, HBV may provide an alternative to reduce antibiotic use in the poultry industry.

【 授权许可】

Unknown