Serum ferritin contributes to racial or geographic disparities in metabolic syndrome in Taiwan

Public Health Nutrition

Shiue-Ming Lin¹  Chyi-Huey Bai¹  Wen-Harn Pan¹  Jane C-J Chao¹  Ni-Hsin Chou¹  Chi-Mei Wang¹  Yi-Chun Chen¹  Jung-Su Chang¹ 

关键词: Metabolic syndrome;    Serum ferritin;    Odds ratio;    Ethnicity;    Taiwanese Indigenous;   

DOI  :  10.1017/S1368980013001596

学科分类：卫生学

来源: Cambridge University Press

【 摘 要 】

AbstractObjectivesAsians and Pacific Islanders have higher circulating serum ferritin (SF) compared with Caucasians but the clinical significance of this is unclear. There is a higher prevalence of metabolic syndrome (MetS) in Taiwanese Indigenous than Han Chinese. Genetically, Indigenous are related to Austronesians and account for 2 % of Taiwan's population. We tested the hypothesis that accumulation of Fe in the body contributes to the ethnic/racial disparities in MetS in Taiwan.DesignA population-based, cross-sectional study.SettingNational Nutrition and Health Survey in Taiwan and Penghu Island.SubjectsA total of 2638 healthy adults aged ≥19 years. Three ethnic groups were included.ResultsHan Chinese and Indigenous people had comparable levels of SF. Austronesia origin was independently associated with MetS (OR = 2·61, 95 % CI 2·02, 3·36). After multiple adjustments, the odds for MetS (OR = 2·49, 95 % CI 1·15, 5·28) was significantly higher among Indigenous people in the highest SF tertile compared with those in the lowest tertile. Hakka and Penghu Islanders yielded the lowest risks (OR = 1·08, 95 % CI 0·44, 2·65 and OR = 1·21, 95 % CI 0·52, 2·78, respectively). Indigenous people in the highest SF tertile had increased risk for abnormal levels of fasting glucose (OR = 2·34, 95 % CI 1·27, 4·29), TAG (OR = 1·94, 95 % CI 1·11, 3·39) and HDL-cholesterol (OR = 2·10, 95 % CI 1·18, 3·73) than those in the lowest SF tertile.ConclusionsOur results raise the possibility that ethnic/racial differences in body Fe store susceptibility may contribute to racial and geographic disparities in MetS.

【 授权许可】

Unknown