Clinical, pathological and laboratorial changes in the copper chronic intoxication in sheep

Ciência Rural

Rangel, Josephina Montanari Rosa³  Salvador, Sandro César¹  Lemos, Ricardo Antônio Amaral³  Osório, Ana Luiza Alves Rosa³  Moraes, Sheila Silva²  Nakazato, Luciano¹  Martins, Sérgio¹ 

[1] Empresa Brasileira de Pesquisa Agropecuária, Campo Grande;Universidade Federal do Mato Grosso do Sul, Campo Grande

关键词: copper poisoning;    sheep;    copper;   

DOI  :  10.1590/S0103-84781997000300016

学科分类：农业科学（综合）

来源: Universidade Federal de Santa Maria * Centro de Ciencias Rurais

【 摘 要 】

In order to evaluate the copper toxicity in sheep, 4 groups of animals have been administered Copper sulfate at the dosagens 15, 30, 60 and 120ppm, until signs of intoxication occurred. There was still a 5th group, as control. These animals have been submitted to daily physical examination and periodical determinations of AST and gGT serum levels. Those that have died during the study have been necropsied and the fragments of the main organs have been histologically examined. The liver copper levels have also been determined. In all groups there have been cases of intoxication, which occurred between the 80th and 116th day. The principal clinical signs of intoxication were: depression, jaundice, haemoglobinuria and diarrhea. It has been observed raised levels of gGT and AST between 21st and 43rd day before the clinical signs appeared, getting the maximum value during the clinical stage. The main histological changes were present in the liver and kidneys, showing degeneration lesions. Lever copper values varied from 1097.5 is 1366.9ppm, showing the same level or twice the value considered to be the maximum normal limit, assuring thus that this element has been responsible for the pathological clinical process. All the dosagens used in the study have been considered potentially toxic to this species.

【 授权许可】

CC BY-NC