Measurement of Erythrocyte Na, K-ATPase Activity in Normal Pregnant Women

Endocrine Journal

HIDENORI OGASAWARA²  MITSUSHIGE NISHIKAWA²  MASATERU HORIMOTO²  MASAYOSHI YOSHIMURA²  NORIO YOSHIKAWA²  MITSUO INADA²  ISAMU SAWARAGI¹ 

[1] Department of Obstetrics and Gynecology, Kansai Medical University;Second Department of Internal Medicine, Kansai Medical University

关键词: Na;    K-ATPase;    Pregnancy;    Thyroid hormone;    Metabolic status;    hCG;   

DOI  :  10.1507/endocrj.40.171

学科分类：内分泌与代谢学

来源: Japan Endocrine Society

【 摘 要 】

References(30)Cited-By(4)To investigate the peripheral metabolic status during normal pregnancy, we measured the number of erythrocyte Na, K-ATPase units as well as the cation transport activity of the pump from 32 normal pregnant women and 12 normal controls. The number of pump units determined by maximal ouabain binding to erythrocyte in normal pregnancy was significantly higher than that in normal controls (mean±SEM: 0.52±0.03 vs. 0.39±0.04pmol/109RBC, P<0.05). The total cation transport activity of the pump measured by 86Rb uptake also significantly increased during pregnancy (98.9±6.4 vs. 73.1±5.4nmol/109 RBC, P<0.01). However, the mean cation transport activity per pump unit, which was presumed to be an indicator of the peripheral metabolic status, was unchanged in any of three trimesters when compared with that in normal controls. Serum FT4 levels measured by two different methods were significantly lower in the third trimester than in the first trimester (P<0.01). In conclusion, erythrocyte Na, K-ATPase activity per pump unit is normal in pregnant women, suggesting that the peripheral metabolic status in pregnancy seems to be normal. Increases in both the number and function of the pump may be influenced by factors other than thyroid function.

【 授权许可】

Unknown