Longer HSD11B2 CA-repeat in impaired glucose tolerance and type 2 diabetes

Endocrine Journal

Noriyoshi Yamakita¹  Yukinori Isomura³  Nobuki Takada⁷  Tomoatsu Mune²  Hiroyuki Morita⁵  Perrin C. White⁴  Yoritsuna Yamamoto⁷  Tetsuya Suwa³  Jun Takeda³  Kohei Kaku²  Noriyuki Takeda⁶  Akihiko Sasaki⁶  Makoto Hayashi¹ 

[1] Department of Internal Medicine, Matsunami General Hospital, Gifu 501-6062, Japan;Division of Diabetes, Endocrinology and Metabolism, Kawasaki Medical School, Kurashiki 701-0192, Japan;Department of Diabetes and Endocrinology, Gifu University, Gifu 501-1194, Japan;Division of Pediatric Endocrinology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA;Department of General Medicine, Gifu University, Gifu 501-1194, Japan;Department of Internal Medicine, Murakami Memorial Hospital, Gifu 500-8523, Japan;Department of Medicine, Japan Selfdefence Force Gifu Hospital, Kakamigahara 504-8701, Japan

关键词: 11β-hydroxysteroid dehydrogenase type 2;    Cortisol;    Cortisone;    Insulin;    Pancreas;   

DOI  :  10.1507/endocrj.EJ12-0108

学科分类：内分泌与代谢学

来源: Japan Endocrine Society

【 摘 要 】

References(22)Cited-By(2)Type 2 11β-hydroxysteroid dehydrogenase encoded by the HSD11B2 gene converts cortisol to inactive cortisone, and alteration in this enzymatic activity might affect glucose homeostasis by affecting circulating levels or tissue availability of glucocorticoids.We investigated the association of HSD11B2 variant with glucose homeostasis.Subjects with normal glucose tolerance (n=585), impaired glucose tolerance (n=202) and type 2 diabetes (n=355) were genotyped for a highly polymorphic CA-repeat polymorphism in the first intron of HSD11B2.Allele and genotype frequencies differed between normal and impaired glucose tolerance (P = 0.0014 and 0.0407, respectively; 4 degree of freedom) or type 2 diabetes (P = 0.0053 and 0.0078), with significant linear trends between the repeat length and the phenotype fraction.In normal subjects, total CA-repeat length was negatively correlated with fasting insulin and HOMA-β.Thus, subjects having more CA repeats are susceptible to developing abnormal glucose tolerance, whereas normal subjects carrying more CA repeats appeared to have frugal characteristics in insulin secretion.

【 授权许可】

Unknown