High Genetic Stability of TM1 and TM2 Strains of Subtype B Feline Immunodeficiency Virus in Long-Term Infection

Journal of Veterinary Medical Science

Takeshi MIKAMI²  Yukinobu TOHYA²  Kazuya NAKAMURA¹  Takayuki MIYAZAWA¹  Yorihiro NISHIMURA³  Yasuhiro IKEDA² 

[1] Department of Veterinary Public Health, Obihiro University of Agriculture and Veterinary Medicin;Department of Veterinary Microbiology, Graduate School of Agricultural and Life Sciences, The University of Tokyo;Department of Virology II, National Institute of Infectious Diseases

关键词: FIV;    mutation;    subtype;   

DOI  :  10.1292/jvms.66.287

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

References(15)Cited-By(7)To know the genetic changes of feline immunodeficiency virus (FIV) in long-term infection in cats, we inoculated three specific pathogen-free cats with FIV isolates and determined a partial env sequence covering the V3-V5 region. In 2 cats infected with subtype B strains TM1 and TM2, only one amino acid change in region V3 was observed at 9 years post infection (y.p.i.), and no nucleotide substitutions were observed between 9 and 10 y.p.i., indicating that these strains are genetically stable. On the other hand, in a cat infected with subtype A strain Petaluma at 8.7 y.p.i., 3 nucleotide insertions (one amino acid insertion) in region V5, and 1 synonymous nucleotide substitution and 2 non-synonymous nucleotide substitutions in region V5, were observed.

【 授权许可】

Unknown