Actions and Mode of Actions of FGF19 Subfamily Members

Endocrine Journal

Seiji FUKUMOTO¹ 

[1] Division of Nephrology & Endocrinology, Department of Medicine, University of Tokyo Hospital

关键词: Hypophosphatemia;    Hyperphosphatemia;    Klotho;    FGF;   

DOI  :  10.1507/endocrj.KR07E-002

学科分类：内分泌与代谢学

来源: Japan Endocrine Society

【 摘 要 】

References(52)Cited-By(38)Fibroblast growth factors (FGFs) are humoral factors with diverse biological functions. While most FGFs were shown to work as local factors regulating cell growth and differentiation, recent investigations indicated that FGF19 subfamily members, FGF15/19, FGF21 and FGF23 work as systemic factors. FGF15/19 produced by intestine inhibits bile acid synthesis and FGF21from liver is involved in carbohydrate and lipid metabolism. In addition, FGF23 was shown to be produced by bone and regulate phosphate and vitamin D metabolism. Furthermore, these FGFs require klotho or βklotho for their actions in addition to canonical FGF receptors. It is possible that these FGFs together with their receptor systems might be targets for novel therapeutic measures in the future.

【 授权许可】

Unknown