Elevated Plasma Immunoreactive Neuropeptide Y Concentrations and Its Increased Urinary Excretion in Patients with Advanced Diabetic Nephropathy

Endocrine Journal

CHIHARU SATOH⁶  MOTOJI FUKUDA⁶  KAZUHITO TOTSUNE⁶  MAKOTO OHNEDA⁶  SUSUMU OGAWA⁶  TORAICHI MOURI²  TOKUTARO SATO⁵  FUMITOSHI SATOH⁶  HIROTAKA NAGAKUBO⁶  KAZUHIKO SUGIMURA⁶  OSAMU MURAKAMI⁶  KAZUHIRO TAKAHASHI³  MASAHIKO SONE⁴  TAMAMI YABE¹ 

[1] Iwadeyama Hospital;Division of Neuroendocrinology, Mouri Clinic;Department of Molecular Biology and Applied Physiology, Tohoku University School of Medicine;Department of Medicine, National Iwate Hospital;the Rehabilitation Medicine, Tohoku University School of Medicine;Second Department of Internal Medicine, Tohoku University School of Medicine

关键词: Neuropeptide Y;    Diabetes;    Diabetic Nephropathy;    Urine;   

DOI  :  10.1507/endocrj.46.139

学科分类：内分泌与代谢学

来源: Japan Endocrine Society

【 摘 要 】

References(38)Cited-By(13)Neuropeptide Y (NPY) is a potent vasoconstrictor peptide that is abundant in the brain and the peripheral sympathetic nervous system. In the present study we investigated possible changes in plasma immunoreactive (IR)-NPY concentrations and urinary IR-NPY excretion in patients with non-insulin dependent diabetes mellitus (NIDDM) and the relationship to diabetic complications, such as nephropathy and neuropathy. IR-NPY in plasma and urine was measured by radioimmunoassay in 69 patients with NIDDM. Plasma IR-NPY concentrations in patients with advanced nephropathy (creatinine clearance <30ml/min) (100.5±10.3pmol/l, n=9, mean±SEM) were higher than in the control subjects (55.0±6.8 pmol/l, n=15) (P<0.02). Urinary excretion of IR-NPY and fractional excretion of NPY were also increased in the patients with advanced nephropathy. Sephadex G-50 column chromatography of the urine extracts obtained from healthy subjects, diabetic patients with renal failure and non-diabetic patients with renal failure showed an immunoreactive peak eluting in the NPY position. On the other hand, neither plasma nor urinary IR-NPY was high in patients with retinopathy, or in patients with peripheral neuropathy. The present study has, for the first time, shown high plasma IR-NPY concentrations and urinary IR-NPY excretion in NIDDM patients with advanced nephropathy.

【 授权许可】

Unknown