Postprandial Reactive Hypoglycemia in an Oldest-old Patient Effectively Treated with Low-dose Acarbose

Endocrine Journal

Takayuki HOSOI²  Atsushi ARAKI¹  Yoshiaki TAMURA¹  Seijiro MORI¹  Toshiyuki HORIUCHI¹  Yuko CHIBA¹ 

[1] Department of Endocrinology, Tokyo Metropolitan Geriatric Hospital;Present Address: Department of Advanced Medicine, National Center for Geriatrics and Gerontology

关键词: Reactive hypoglycemia;    Oldest-old patient;    Oral glucose tolerance test;    Oral sucrose tolerance test;    Alpha-glucosidase inhibitor;   

DOI  :  10.1507/endocrj.K05-140

学科分类：内分泌与代谢学

来源: Japan Endocrine Society

【 摘 要 】

References(10)Cited-By(9)We recently encountered a 96-year-old Japanese woman who suffered from frequent hypoglycemia. Endocrinological and imaging data eliminated the possibility of insulinoma, whereas oral glucose tolerance testing revealed impaired glucose tolerance and subsequent reactive hypoglycemia. The patterns between insulin or C-peptide secretions and glucose excursions demonstrated that the discrepancy occurred in the late postprandial stage. Administration of small doses of alpha-glucosidase inhibitor (α-GI) dramatically inhibited the rapid rise and subsequent precipitous fall of plasma glucose. Reactive hypoglycemia may be one of the important cause of hypoglycemia in the elderly, and α-GI could effectively and safely prevent such hypoglycemic attacks in those patients.

【 授权许可】

Unknown