Involvement of Hypothalamic Glutamate in Cisplatin-Induced Emesis in Suncus murinus (House Musk Shrew)

Journal of Pharmacological Sciences

Atsushi Yamatodani²  Keiko Asano²  Sze Wa Chan¹  John A. Rudd¹  Ge Lin¹  Kouichi Yamamoto² 

[1] Department of Pharmacology, Faculty of Medicine, The Chinese University of Hong Kong, China;Department of Medical Physics and Engineering, Division of Health Sciences, Graduate School of Medicine, Osaka University, Japan

关键词: glutamate;    microdialysis;    Suncus murinus;   

DOI  :  10.1254/jphs.08333SC

学科分类：药学

来源: Nihon Yakuri Gakkai Henshuubu / Japanese Pharmacological Society

【 摘 要 】

References(15)Cited-By(4)We investigated the effect of cisplatin on glutamate release in the hypothalamus of Suncus murinus measured by brain microdialysis. Dialysis samples were collected every 20 min for 1 h before and 3 h after the cisplatin (30 mg/kg, i.p.) administration with the animals also being observed for the development of emesis. Cisplatin increased glutamate levels within 1 h and this was closely associated with the occurrence of emesis. Pretreatment with the 5-HT3–receptor antagonist ondansetron (2 mg/kg, i.p.) inhibited both the emesis and the increased glutamate levels. These results suggest that hypothalamic glutamate is involved in cisplatin-induced emesis in Suncus murinus.

【 授权许可】

Unknown