Supplemented zinc does not alter mood in healthy older European adults – a randomised placebo-controlled trial: the Zenith study

Public Health Nutrition

Ellen EA Simpson¹  Maud Andriollo-Sanchez¹  Angela Polito¹  Chris McConville¹  JJ Strain¹  Charles Coudray¹  Gordon Rae¹  Jacqueline O’Connor¹  Barbara J Stewart-Knox¹ 

关键词: Zinc;    Intervention;    Mood;    Affect;    PANAS;    Elderly;    Zenith;   

DOI  :  10.1017/S1368980010002764

学科分类：卫生学

来源: Cambridge University Press

【 摘 要 】

ObjectiveOlder people are vulnerable to zinc deficiency, which may impact upon their mood. This randomised, placebo-controlled, double-blind intervention study aimed to investigate the effect of oral zinc gluconate supplementation (15 mg/d; 30 mg/d; and placebo) on subjective mood (affect) in older Europeans.SubjectsHealthy volunteers (n 387) aged 55–87 years were recruited.SettingVolunteers in Rome (Italy; n 108) and Grenoble (France; n 91) were aged 70–87 years and those in Coleraine (Northern Ireland; n 93) and Clermont-Ferrand (France; n 95) were aged 55–70 years.DesignMood was measured using the Positive and Negative Affect Scale on four occasions per day over 4 d at baseline, 3 and 6 months post-intervention.ResultsMixed ANOVA indicated that neither positive nor negative affect altered in response to zinc (15 mg/d or 30 mg/d) compared to placebo in either the 55–70 years or the ≥70 years age group.ConclusionsThese results suggest that zinc does not benefit mood in healthy older people.

【 授权许可】

Unknown