Factors associated with epidemic multiresistant Pseudomonas aeruginosa infections in a hospital with AIDS-predominant admissions

Brazilian Journal of Infectious Diseases

Oliveira, Raquel Vasconcellos C. de¹  Gomes, Marisa Zenaide Ribeiro²  Conceição, Magda de Souza da¹  Machado, Carolina Romero¹  Souza, Cristina Vieira de¹  Lourenço, Maria Cristina da Silva¹  Asensi, Marise Dutra² 

[1] FIOCRUZ, Brazil;Fundação Oswaldo Cruz, Brazil

关键词: Pseudomonas aeruginosa;    risk factors;    disease outbreaks;    molecular epidemiology;    acquired immunodeficiency syndrome;   

DOI  :  10.1590/S1413-86702012000300001

来源: Contexto

【 摘 要 】

INTRODUCTION: Infections caused by multiresistant Pseudomonas aeruginosa (MR-PA) have been associated with persistent infections and high mortality in acquired immunodeficiency syndrome (AIDS) patients. Therefore, understanding the predisposing factors for infection/colonization by this agent is critical for controlling outbreaks caused by MR-PA in settings with AIDS patients.
OBJECTIVEAND METHODS: To analyze the presence of factors associated with the acquisition of an epidemic MR-PA strain in a hospital with AIDS-predominant admission. A case-control study was carried out in which cases and controls were gathered from a prospective cohort of all hospitalized patients in an infectious disease hospital during a five-year study period.
RESULTS: Multivariate logistic regression analysis demonstrated that enteral nutrition OR = 14.9), parenteral nutrition (OR = 10.7), and use of ciprofloxacin (OR = 8.9) were associated with a significant and independent risk for MR-PA acquisition.
CONCLUSIONS: Although cross-colonization was likely responsible for the outbreaks, the use of ciprofloxacin was also an important factor associated with the acquisition of an epidemic MR-PA strain. More studies are necessary to determine whether different types of nutrition could lead to modification of gastrointestinal flora, thereby increasing the risk for infection/colonization by MR-PA in this population.

【 授权许可】

CC BY-NC-ND