Journal of Veterinary Medical Science | |
Protective Effect of Clostridium septicum Alpha-Toxoid Vaccine against Challenge with Spores in Guinea Pigs | |
Eiji OISHI1  Toshiaki OHGITANI1  Osamu SASAKI1  Katsuhiko AMIMOTO1  Sotoyuki OTA1  Shigeji KATAYAMA1  Makoto ISOGAI1  | |
[1] Division of Veterinary Microbiology, Kyoto Biken Laboratories | |
关键词: alpha-toxin; Clostridium septicum; toxoid; | |
DOI : 10.1292/jvms.64.67 | |
学科分类:兽医学 | |
来源: Japanese Society of Veterinary Science | |
【 摘 要 】
References(11)Cited-By(6)The protective effect of an alpha-toxoid vaccine of Clostridium septicum purified alpha-toxin was investigated in guinea pigs. Purified alpha-toxin was treated with formalin to make toxoid, and alpha-toxoid vaccine was prepared by mixing alpha-toxoid (4 to 64 μg/dose) with an aluminum phosphate gel as adjuvant. Guinea pigs were immunized twice with different doses of alpha-toxoid vaccine, and challenged with spores of C. septicum. The guinea pigs surviving after challenge had been immunized with 8 μg/dose or more of alpha-toxoid. All these animals produced titers of 20 units or higher of antitoxin at the challenge. The results suggest that C. septicum alpha-toxin plays an important role in protection against challenge with spores in guinea pigs.
【 授权许可】
Unknown
【 预 览 】
Files | Size | Format | View |
---|---|---|---|
RO201911300209123ZK.pdf | 68KB | download |