Associations of apolipoprotein A5 (APOA5), glucokinase (GCK) and glucokinase regulatory protein (GCKR) polymorphisms and lifestyle factors with the risk of dyslipidemia and dysglycemia in Japanese — a cross-sectional data from the J-MICC Study

Endocrine Journal

Mariko Naito^1,9  Toshiro Takezaki¹⁰  Kenji Wakai^1,9  Sadao Suzuki³  Keitaro Matsuo⁵  Nobuyuki Hamajima^1,9  Hirokazu Uemura¹¹  Rieko Okada^1,9  Emi Morita^1,9  Kazuyo Nakamura⁷  Naoyuki Takashima⁶  Hideo Tanaka⁵  Keizo Ohnaka⁴  Yoshiyuki Watanabe^1,8  Asahi Hishida^1,9  Haruo Mikami¹  Michiaki Kubo² 

[1] Division of Epidemiology, Chiba Cancer Center Research Institute, Chiba 260-8717, Japan;Center for Genomic Medicine, RIKEN, Yokohama 230-0045, Japan.;Department of Public Health, Nagoya City University Graduate School of Medical Sciences, Nagoya 467-8601, Japan;Department of Geriatric Medicine, Kyushu University Graduate School of Medical Sciences, Fukuoka 812-8582, Japan;Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya 464-8681, Japan;Department of Health Science, Shiga University of Medical Science, Otsu 520-2192, Japan;Department of Preventive Medicine, Faculty of Medicine, Saga University, Saga 849-8501, Japan;Department of Social Medicine and Cultural Sciences, Kyoto Prefectural University of Medicine, Kyoto 602-8566, Japan;Department of Preventive Medicine, Nagoya University Graduate School of Medicine, Nagoya 466-8550, Japan;Department of International Island and Community Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima 890-8544, Japan;Department of Preventive Medicine, Institute of Health Biosciences, the University of Tokushima Graduate School, Tokushima 770-8503, Japan

关键词: APOA5;    GCK;    Single nucleotide polymorphisms;    Dyslipidemia;    Dysglycemia;   

DOI  :  10.1507/endocrj.EJ11-0310

学科分类：内分泌与代谢学

来源: Japan Endocrine Society

【 摘 要 】

References(39)Cited-By(11)This study examined the associations of the APOA5 T-1131C (rs662799), G553T (Cys185Gly, rs2075291), GCK G-30A (rs1799884), GCKR A/G at intron 16 (rs780094) and T1403C (Leu446Pro, rs1260326) polymorphisms with serum lipid and glucose levels in Japanese, considering lifestyle factors.Study subjects were 2,191 participants (aged 35-69 years, 1,159 males) enrolled in the Japan Multi-Institutional Collaborative Cohort (J-MICC) Study.Dyslipidemia was defined as fasting serum triglycerides (FTG) ≥ 150 mg/dL and/or HDL-cholesterol (HDL-C) < 40 mg/dL, while dysglycemia was as fasting blood sugar (FBS) ≥ 110 mg/dL. When those with APOA5 -1131 T/T or 553 G/G were defined as references, those with APOA5 -1131 T/C, C/C or 553 G/T, T/T demonstrated significantly elevated risk of dyslipidemia (age- and sex-adjusted odds ratio: 1.77 [95% confidence interval:1.39-2.27], 3.35 [2.41-4.65], 2.23 [1.64-3.02] and 13.78 [3.44-55.18], respectively).Evaluation of FTG, HDL-C or FBS levels according to the genotype revealed that FTG and HDL-C levels were significantly associated with the APOA5 T-1131C and G553T polymorphisms, FTG with the GCKR rs780094 and rs1260326 polymorphisms, and FBS with the GCKR rs780094 and rs1260326 polymorphisms.Moreover, a significant positive interaction between APOA5 553 G/T+T/T genotypes and fat intake ≥ 25% of total energy for the risk of dyslipidemia was observed.Our cross-sectional study confirmed the essential roles of the polymorphisms of the APOA5, GCK and GCKR in the lipid or glucose metabolism disorders, and suggested the importance of fat intake control in the individualized prevention of dyslipidemia.

【 授权许可】

Unknown