Canine Coronavirus Infections in Japan: Virological and Epidemiological Aspects

Journal of Veterinary Medical Science

Chikashi BANDAI²  Masami MOCHIZUKI¹  Nozomi MASUYA²  Shinryo ISHIGURO²  Tsutomu HOHDATSU³ 

[1] Laboratory of Clinical Microbiology, Kyoritsu Shoji Corporation, Tokyo 102-0073, Japan;Central Laboratories, Kyoritsu Shoji Corporation, 2-9-22 Takamihara, Kukisaki, Ibaraki 300-1252, Japan;Department of Veterinary Infectious Diseases, School of Veterinary Medicine and Animal Sciences, Kitasato University, Towada, Aomori 034-0021, Japan

关键词: canine;    canine coronavirus;    diarrhea;    enteritis;   

DOI  :  10.1292/jvms.61.731

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

References(28)Cited-By(17)Ten strains, eight field and two reference laboratory strains, of canine coronavirus (CCV) were comparatively examined with respect to antigenic relationships and pathogenic potential in dogs. With monoclonal antibodies and hyperimmune antisera to feline coronavirus and CCV, respectively, varying degrees of antigenic diversities were found among the strains by neutralization and immunofluorescence assays, but it was felt that they belong to one serotype. Specific-pathogen-free puppies experimentally inoculated with some CCV strains manifested clinical symptoms, but there was a difference in their virulence. In order to elucidate the prevalence of CCV infections in dogs in Japan, we tested for neutralizing antibodies to CCV in 467 field dogs, and found a prevalence of 44.1%. Moreover, by using nested reverse transcriptase-polymerase chain reaction on rectal swabs of 100 diarrheic dogs recently presented in veterinary clinics, evidence of CCV in 16% of these specimens was found. The results suggested that CCV infection is more widespread than expected in dogs, and that CCV is a significant etiologic factor in canine diarrhea also in Japan.

【 授权许可】

Unknown