Bovine Milk Enhances the Oxidative Burst Activity of Polymorphonuclear Leukocytes in Low Concentrations

Journal of Veterinary Medical Science

Yuri ICHIMURA¹  Takeo SAKAI¹  Hitoshi SUGISAWA¹  Takuya ITOU¹ 

[1] Department of Preventive Veterinary Medicine and Animal Health, Nihon University School of Veterinary Medicine

关键词: bovine;    colostrum;    normal milk;    oxidative burst;    polymorphonuclear leukocyte;   

DOI  :  10.1292/jvms.64.1113

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

References(27)Cited-By(3)Bovine milk contains various immunoreactive components, and the activation of polymorphonuclear leukocytes (PMNLs) function in breast-fed infants has been reported. In this study, the effect of milk on the oxidative burst of bovine PMNLs was investigated in vitro. When PMNLs were incubated with 0.1% colostrum or normal milk, the oxidative burst induced by serum-opsonized Staphylococcus aureus was enhanced, and the enhancement declined dose-dependently. The enhancement of the oxidative burst by milk was not due to opsonins but the priming activities. Also, the phorbol 12-myristate 13-acetate (PMA)-induced oxidative burst increased after incubation with 0.1% colostrum, but the colostral enhancement of the oxidative burst was unaffected by the incubation time. These results suggest that bovine milk contains oxidative burst promoting factor(s).

【 授权许可】

Unknown