Journal of Pharmacological Sciences | |
Drug Development Targeting the Glycogen Synthase Kinase-3β (GSK-3β)-Mediated Signal Transduction Pathway: Inhibitors of the Wnt/β-Catenin Signaling Pathway as Novel Anticancer Drugs | |
Toshiyuki Sasaguri1  Fumi Takahashi-Yanaga1  | |
[1] Department of Clinical Pharmacology, Faculty of Medical Sciences, Kyushu University, Japan | |
关键词: Wnt/β-catenin signaling; cancer; glycogen synthase kinase-3β (GSK-3β); drug development; differentiation-inducing factor; | |
DOI : 10.1254/jphs.08R28FM | |
学科分类:药学 | |
来源: Nihon Yakuri Gakkai Henshuubu / Japanese Pharmacological Society | |
【 摘 要 】
References(35)Cited-By(31)Accumulating evidence suggests that the Wnt/β-catenin signaling pathway is often involved in oncogenesis and cancer development. Accordingly, a novel anticancer drug can be developed using inhibitors of this pathway. However, at present, there is no selective inhibitor of this pathway available as a therapeutic agent. Although all the components of the Wnt/β-catenin signaling pathway can be a target for drug development, glycogen synthase kinase-3β (GSK-3β), in particular, may be a good target because GSK-3β is an essential component of the pathway, and activation of this kinase results in the inhibition of the Wnt signaling pathway. We found that the differentiation-inducing factors (DIFs), putative morphogens for Dictyostelium discoideum, inhibit the Wnt/β-catenin signaling pathway via the activation of GSK-3β, resulting in the cell-cycle arrest of human cancer cell lines. In this review, we summarize our recent findings on the antiproliferative effect of DIFs and show the possibility for development of a novel anticancer drug from DIFs and their derivatives.
【 授权许可】
Unknown
【 预 览 】
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RO201911300199396ZK.pdf | 324KB | download |