Changes in Blood Viscosity With Synthetic Protease Inhibitors

Journal of Pharmacological Sciences

Munehiro Niwa²  Tomoyoshi Takahashi³  Shogo Tokudome¹  Hirohisa Nihei¹  Toshiaki Nagai¹  Akira Kurosu¹  Masahito Hitosugi¹ 

[1] Department of Legal Medicine, Dokkyo University School of Medicine;Faculty of Policy Informatics, Chiba University of Commerce;Department of Chemistry, Jikei University School of Medicine

关键词: blood viscosity;    synthetic protease inhibitor;    rheology;   

DOI  :  10.1254/jphs.91.334

学科分类：药学

来源: Nihon Yakuri Gakkai Henshuubu / Japanese Pharmacological Society

【 摘 要 】

References(15)Cited-By(4)We examined the effects on whole blood viscosity and coagulation time of various dosages of the synthetic low-molecular protease inhibitors gabexate mesilate and nafamostat mesilate with an oscillation-type viscometer. When either agent was added, blood viscosity decreased dose-dependently along a sigmoid-like curve. Furthermore, coagulation time was shorter with gabexate mesilate than with nafamostat mesilate owing to the differences of half-life in human blood. Thrombin generation, which results from the activation of coagulation factors, is inhibited by synthetic protease inhibitors and subsequently decreases blood viscosity dose-dependently.

【 授权许可】

Unknown