Plasma Chromogranin A in Pheochromocytoma, Primary Hyperparathyroidism and Pituitary Adenoma in Comparison with Catecholamine, Parathyroid Hormone and Pituitary Hormones

Endocrine Journal

YUKIO MIURA¹  TOSHIYA WATANABE⁴  KAZUMASA SHIMIZU⁴  KUNIHIKO HANEW⁴  KAZUTOSHI MIZUNASHI⁴  HYO EUY SOHN²  TAKAO NOSHIRO⁴  HIROSHI NAGURA³  KEISHI ABE⁴  NORIKO KIMURA³  SATOSHI SHIBUKAWA⁴  WAKAKO MIURA⁴ 

[1] Informatics on Pathophysiology, Tohoku University Graduate School of Informative Science;Department of Internal Medicine, Shakai-Hoken Hospital;Department of Pathology, Tohoku University School of Medicine;2nd Department of Internal Medicine, Tohoku University School of Medicine

关键词: Chromogranin A;    Pheochromocytoma;    Norepinephrine;    Hyperparathyroidism;    Pituitary adenoma;    ELISA;   

DOI  :  10.1507/endocrj.44.319

学科分类：内分泌与代谢学

来源: Japan Endocrine Society

【 摘 要 】

References(24)Cited-By(13)Plasma levels of chromogranin A (CgA) were measured by ELISA in 22 patients with pheochromocytoma (18 non-metastatic, 3 metastatic, and 1 mixed neuroendocrine-neural tumor), 9 patients with primary hyperparathyroidism, and 9 patients with pituitary adenoma. The plasma levels of CgA were compared with norepinephrine, epinephrine, parathyroid hormone and pituitary hormones, i.e., growth hormone and prolactin. In pheochromocytoma, CgA in preoperative plasma of the patients without metastasis was 228±38U/L (mean±SEM) and significantly higher than healthy controls (30±11U/L, n=40). Plasma CgA was decreased after removal of the tumors (28±6.0U/L), except in three patients with metastatic pheochoromocytoma and a mixed neuroendocrine neural tumor. The concentration of CgA in the patients with non-metastatic pheochromocytoma was significantly correlated with that of plasma norepinephrine (P<0.005, r=0.68) and urinary norepinephrine (P<0.05, r=0.65), but not with that of epinephrine. There was an exceptional case in which CgA was extremely high, but the CA level was normal. This tumor was a highly malignant pheochromocytoma with extensive metastases composed of small tumor cells which were occasionally positive for tyrosine hydroxylase immunohistochemically. These cells were considered to be poorly differentiated tumor cells and synthesized a very small amount of norepinephrine. Plasma levels of the patients with primary hyperparathyroidism and the patients with pituitary adenoma were 44±4U/L and 48±8U/L, respectively. Only one patient with a growth hormone-producing pituitary adenoma had a high level of CgA. Plasma CgA is a useful tumor marker for pheochromocytoma, even for malignant pheochromocytoma without elevated CA level, but not for hyperparathyroidism, or pituitary adenoma.

【 授权许可】

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