Is Leptin a Key Factor which Develops Obesity by Ovariectomy?

Endocrine Journal

YUMIKO ABE¹  HIROYUKI SHIMIZU²  TAKAHUMI TSUCHIYA²  YUTAKA UEHARA²  KENJU SHIMOMURA²  MASATOMO MORI² 

[1]Department of Gynecology and Obstetrics, Gunma University School of Medicine

[2]First Department of Internal Medicine Gunma University School of Medicine

关键词: Leptin;    Ovariectomy;    Estrogen;    Genetic obesity;    ob/ob mice;   

DOI  :  10.1507/endocrj.49.417

学科分类：内分泌与代谢学

来源: Japan Endocrine Society

【 摘 要 】

References(23)Cited-By(13)Withdrawal of estrogen by ovariectomy increases adiposity, but decreases the circulating levels of the ob gene product, leptin, which inhibits food intake. The reduction of circulating leptin levels may thus play an important role in the induction of obesity by ovariectomy. To examine this hypothesis, body weight change by ovariectomy was investigated in leptin-deficient genetically obese (ob/ob) mice with leptin supplement. Prior to the operation, obese (ob/ob) female mice were treated with intraperitoneal administration of recombinant mouse leptin (1.0 μg/g body weight/day) for 8 days. Then, half of the leptin-treated mice and their lean littermates were bilaterally ovariectomized and their body weight changes were observed for 56 days. From 16 days after the operation, a significant increase in body weight by ovariectomy was observed only in lean mice without leptin treatment. From 44 days, a significant body weight gain by ovariectomy was observed in leptin-treated obese mice. Ovariectomy significantly increased retroperitoneal white adipose tissue weight in their lean littermates, but not in leptin-treated obese mice. It was suggested that the reduction of circulating leptin levels may play an important role in the increases of acute phase body weight gain by ovariectomy, but during static phase, the direct effects of estrogen withdrawal may appear independent of leptin-mediated effects.

【 授权许可】

Unknown