New Topics in Vasopressin Receptors and Approach to Novel Drugs: Involvement of Vasopressin V1a and V1b Receptors in Nociceptive Responses and Morphine-Induced Effects

Journal of Pharmacological Sciences

Kenji Honda¹  Yukio Takano¹ 

[1] Department of Physiology and Pharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, Japan

关键词: arginine vasopressin;    V1a receptor;    V1b receptor;    nociceptive response;    morphine-induced response;   

DOI  :  10.1254/jphs.08R30FM

学科分类：药学

来源: Nihon Yakuri Gakkai Henshuubu / Japanese Pharmacological Society

【 摘 要 】

References(60)Cited-By(8)Arginine vasopressin (AVP) receptors have been classified into V1a, V1b, and V2 subtypes. Recent studies have demonstrated the involvement of AVP in anti-nociception and in morphine-induced anti-nociception. However, the roles of individual AVP-receptor subtypes have not been fully elucidated. Here, we have summarized the role of V1-receptor subtypes in behavioral responses to noxious stimuli and to morphine. In this review, we focus on studies using mice lacking the V1a receptor (V1a−/− mice) and the V1b receptor (V1b−/− mice).

【 授权许可】

Unknown