Long-Term Effect of Growth Hormone (GH) Treatment on Body Composition in Children with GH Deficiency

Endocrine Journal

RYUICHI KUROMARU¹  NAMI UEYAMA¹  TOSHIRO HARA²  HASSAN MOHAMED SALAMA HASSAN²  HITOSHI KOHNO¹  SUNAO HONDA¹ 

[1] Department of Endocrinology and Metabolism, Fukuoka Children's Hospital;Department of Pediatrics, Faculty of Medicine, Kyushu University

关键词: GH deficiency;    Body composition;    Body cell mass;    Extracellular water;   

DOI  :  10.1507/endocrj.46.Suppl_S35

学科分类：内分泌与代谢学

来源: Japan Endocrine Society

【 摘 要 】

References(18)Cited-By(5)Objective: It is important for GH-deficient children to treat abnormal body composition associated with a metabolic consequence, not only short stature. In this study we evaluated long-term effects of GH therapy on body composition in GH-deficient boys and girls. Subjects and Methods: Fortynine subjects with GH deficiency, 35 boys and 14 girls, 6 to 14 years of age, were studied. All the subjects were treated for three years with recombinant human GH at a weekly dosage of 0.5IU/kg by subcutaneous daily injection. Body composition was measured by bioelectrical impedance analysis (BIA 101), Spectrum II 287, RJL Systems, Detroit, Mich. Results: Body fat (%) decreased significantly during the first three months of GH treatment. These values were maintained low thereafter in boys, in contrast to those which continued to tend upward in girls from the second year of the treatment. Lean body mass (kg) increased significantly with increasing extracellular water (kg) and body cell mass (kg) in both sexes during GH treatment. Conclusion: Our data demonstrate that GH can reduce body fat mass in GH-deficient boys and girls. The gender difference in changes in body fat with age during the course of this study is compatible with that observed in normal children. The rapid increase in extracellular water and the gradual increase in body cell mass both contributed to the steady increase in LBM during GH treatment.

【 授权许可】

Unknown