Anti-Alpha-Enolase Antibodies in Pituitary Disease

Endocrine Journal

Kozo HASHIMOTO⁴  Ke-ita TATSUMI⁵  Yoshio MURAKAMI³  Susumu TANAKA⁵  Nobuyuki AMINO⁵  Toshihiro TAKAO⁴  Yuzuru KATO³  Toru TAKANO⁵  Akira TERAMOTO¹  Noriyoshi YAMAKITA²  Shigeyuki TAHARA¹ 

[1] Department of Neurosurgery, Nippon Medical School;Department of Internal Medicine, Matsunami General Hospital;First Division, Department of Medicine, Shimane Medical University;The Second Department of Internal Medicine, Kochi Medical School;Department of Laboratory Medicine, Osaka University Graduate School of Medicine

关键词: Autoantibody;    Enolase;    Lymphocytic hypophysitis;    Pituitary Adenoma;   

DOI  :  10.1507/endocrj.50.697

学科分类：内分泌与代谢学

来源: Japan Endocrine Society

【 摘 要 】

References(25)Cited-By(26)A previous study reported a high prevalence of autoantibodies to alpha-enolase in lymphocytic hypophysitis and these antibodies efficiently distinguished lymphocytic hypophysitis from pituitary tumors. To confirm this, we examined autoantibodies to alpha-enolase in patients with lymphocytic hypophysitis (n = 17), pituitary non-functioning adenoma (n = 13), other pituitary diseases (n = 17) and other autoimmune diseases (n = 30), and compared to healthy controls (n = 46). Autoantibodies were found in 41.2%, 46.2%, 23.5%, 20.0% and 4.3%, respectively. Our findings indicate that detection of anti-alpha-enolase antibodies is not suitable for specific diagnosis of lymphocytic hypophysitis.

【 授权许可】

Unknown