Pathogenicity of emerging Japanese type 1 porcine reproductive and respiratory syndrome virus in experimentally infected pigs

Journal of Veterinary Medical Science

Tomoyuki SHIBAHARA³  Yoshiko KURODA¹  Makoto YAMAKAWA¹  Michihiro TAKAGI¹  Hiroshi ISEKI¹  Hiroshi TSUNEMITSU²  Kenji KAWASHIMA³ 

[1] Viral Disease and Epidemiological Research Division, National Institute of Animal Health, National Agriculture and Food Research Organization, 3�?1�?5 Kannondai, Tsukuba, Ibaraki 305�?0856, Japan;Dairy Hygiene Research Division, National Institute of Animal Health, National Agriculture and Food Research Organization, Hitsujigaoka, Toyohira-ku, Sapporo, Hokkaido 062�?0045, Japan;Pathology and Pathophysiology Research Division, National Institute of Animal Health, National Agriculture and Food Research Organization, 3�?1�?5 Kannondai, Tsukuba, Ibaraki 305�?0856, Japan

关键词: porcine reproductive and respiratory syndrome virus;    swine;    type 1 PRRSV;   

DOI  :  10.1292/jvms.15-0189

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

References(14)To clarify the pathogenicity of Japanese type 1 porcine reproductive and respiratory syndrome virus (PRRSV) isolate in experimentally infected pigs, we evaluated clinical signs and monitored viremia for 21 days post-inoculation (dpi). Lungs were mottled, tanned and reddish in appearance; had lesions predominantly in the cranial, middle and accessory lobes; and failed to collapse at 10 dpi. Although microscopic lesions of lungs were reproduced using the Japanese emerging type 1 PRRSV isolate under experimental conditions, no significant differences were noted between the challenge and control groups regarding mean rectal temperature and daily weight gain. These results provide useful insights into the limited pathogenicity of single infection with the Japanese type 1 PRRSV isolate in piglets, which differ from findings in reported field cases.

【 授权许可】

Unknown