Insulin-Like Growth Factors (IGFs) and IGF-Binding Proteins (IGFBP-1, -2 and -3) in Diabetic Pregnancy: Relationship to Macrosomia

Endocrine Journal

YASUE OMORI¹  KEIKO YANAGISAWA¹  SATOMI MINEI¹  TAMAKI NAGASHIMA¹  TOSHIO TSUSHIMA²  MAYUMI SANAKA¹  YAN-JUN LIU¹ 

[1] Department of Medicine III (Diabetes Center), Institute of Clinical Endocrinology, Tokyo Women's Medical College;Department of Medicine II, Institute of Clinical Endocrinology, Tokyo Women's Medical College

关键词: Diabetic pregnancy;    Macrosomia;    Insulin-like growth factor-I;    -II (IGF-I;    IGF-II);    Insulin-like growth factor-binding proteins (IGFBP-1;    -2;    -3);   

DOI  :  10.1507/endocrj.43.221

学科分类：内分泌与代谢学

来源: Japan Endocrine Society

【 摘 要 】

References(45)Cited-By(9)To evaluate the role of insulin-like growth factors (IGFs) and IGF-binding proteins (IGFBPs) in exessive fetal growth (macrosomia) in diabetic pregnancy, 84 insulin-treated diabetic mothers and their infants were tested for serum concentrations of IGF-I, IFG-II, and IGFBP-1, -2 and -3. These parameters were correlated with the birth weight of neonates and placental weight. IGF-I and II levels were determined by specific radioimmunoassays (RIAs) after serum samples were extracted with aid-ethanol. IGFBPs were measured by Western immunoblot with specific antibodies to the respective IGFBP species. Serum concentrations of both IGF-I and IGF-II in mothers with either IDDM or NIDDM increased with the gestational period, reached a plateau at the third trimester, and returned to non-pregnant levels within 7 days after delivery. These values were not different from those in normal mothers before and throughout pregnancy. As previously reported, IGF-I concentrations in cord serum of neonates born to diabetic mothers were (P<0.01) higher than those of newborns of normal mothers. Likewise, cord blood IGF-II levels were 2-fold higher in babies of diabetic mothers (P<0.001). Fetal IGF-I and IGF-II correlated with each other and with maternal HbA1C, and they positively correlated with either birth weight or placental weight. Cord IGFBP-3 concentrations were significantly higher in diabetic pregnancy, but IGFBP-2 concentrations were not different from those in normal pregnancy. Cord IGFBP-1 concentrations were significantly higher only in babies of mothers with IDDM. None of these cord IGFBP concentrations correlated with birth weight or placental weight. The data suggest that fetal IGF-II, like IGF-I, is involved in fetal and placental growth in diabetic pregnancy. The role of IGFBPs remained to be determined.

【 授权许可】

Unknown