Apoptosis and Cell Proliferation in Rat Hepatocytes Induced by Barbiturates

Journal of Veterinary Medical Science

Kenichi HAYASHI¹  Satoshi FURUKAWA²  Seiichi IKEYAMA³  Kosuke OKADA³  Tohru TAMURA¹  Masanobu GORYO³  Koji USUDA¹  Yasuo MIYAMOTO¹  Yohko FUJIEDA¹ 

[1] Shiraoka Research Station of Biological Science, Nissan Chemical Industries, Ltd., Shiraoka, Saitama 349-0294, Japan;Shiraoka Research Station of Biological Science, Nissan Chemical Industries, Ltd., Shiraoka, Saitama 349-0294 and Department of Veterinary Pathology, Faculty of Agriculture, Iwate University, Morioka, Iwate 020-8550, Japan;Department of Veterinary Pathology, Faculty of Agriculture, Iwate University, Morioka, Iwate 020-8550, Japan

关键词: apoptosis;    cell proliferation;    liver;    phenobarbital;    rat;   

DOI  :  10.1292/jvms.62.23

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

References(26)Cited-By(8)To examine the effect on cell population in hepatocytes of phenobarbital (PB) and other barbiturates, PB, allobarbital (ALB), barbital sodium (BS) and barbituric acid (BA) were given orally to male rats for 7 consecutive days. Although there was no apparent change in non-promoting BA, hepatomegaly was induced by PB, BS and ALB, which are promoters of hepatocarcinogenesis. In PB- and BS-treated livers, hepatomegaly was attributable to hepatocyte proliferation and enzyme induction. In ALB-treated liver, it was attributable to enzyme induction. The level of cell proliferation was reduced to less than the control values following withdrawal of PB, ALB and BS. It seemed that the degree of suppression of cell proliferation following withdrawal of these compounds correlated to the degree of cell proliferation (PB>BS>ALB) during treatment. In PB-treated liver, apoptosis was induced during treatment, serving to eliminate the excess of hepatocytes. This suggests that short-term administration of PB neither induced suppression of apoptosis nor disturbed homeostasis of hepatocyte populations.

【 授权许可】

Unknown