Effects of Dopamine, Dobutamine, Amrinone and Milrinone on Regional Blood Flow in Isoflurane Anesthetized Dogs

Journal of Veterinary Medical Science

Denji TOBATA¹  Koji TAKAO¹  Nobuo SASAKI¹  Ryohei NISHIMURA¹  Manabu MOCHIZUKI¹ 

[1] Laboratory of Veterinary Surgery, Graduate School of Agricultural and Life Sciences, The University of Tokyo

关键词: amrinone;    canine;    dobutamine;    dopamine;    milrinone;   

DOI  :  10.1292/jvms.66.1097

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

References(39)Cited-By(9)The effects of cyclic AMP increasing cardiotonics (dopamine, dobutamine, amrinone and milrinone) on the blood flow in most organs were compared using colored microsphere technique in isoflurane-anesthetized dogs. Dopamine increased blood flow in ventricular myocardium. Furthermore dopamine induced the increase in blood flow in intestine and kidney at low to middle dose, but not at high dose. Dobutamine induced the highest increase in blood flow in ventricular myocardium and skeletal muscle among the drugs evaluated at middle and high doses. Amrinone and milrinone increased blood flow in ventricular myocardium almost same with catecholamines, and milrinone decreased vascular resistance moderately in most other organs. Milrinone might be more useful than catecholamines for improvement of congestive heart failure or peripheral circulatory failure accompanied with exceeded vasoconstriction.

【 授权许可】

Unknown