Cloning of cDNA Encoding Canine Endothelin Receptors and Their Expressions in Normal Tissues

Journal of Veterinary Medical Science

Kenichi MASUDA²  Nobutaka YASUDA¹  Hajime TSUJIMOTO¹  Shinpei KAWARAI¹  Keitaro OHMORI¹  Toshihiro TSUKUI³  Sadatoshi MAEDA⁴ 

[1] Department of Veterinary Internal Medicine, Graduate School of Agricultural and Life Sciences, The University of Tokyo;Laboratory for Vaccine Design, Research Center for Allergy and Immunology, Yokohama Institute, RIKEN (The Institute of Physical and Chemical Research);Nippon Zenyaku Kogyo Co., Ltd.;Laboratory of Veterinary Internal Medicine, Faculty of Applied Biological Sciences, Gifu University

关键词: canine;    endothelin-1;    endothelin receptor;   

DOI  :  10.1292/jvms.67.1075

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

References(26)Cited-By(3)The receptors for endothelin (ET) family, ETA and ETB, were molecularly cloned and the expression of ETA and ETB as well as preproendothelin-1 (PPET-1, precursor of ET-1) was examined in normal canine tissues by RT-PCR. The entire open reading frames of the canine ETA and ETB were shown to encode 427 and 442 amino acid residues, respectively, showing from 87.4 to 97.3% sequence similarity to human, mouse, and rat counterparts. ETA and ETB mRNAs were ubiquitously expressed in a variety of canine tissues in this study and PPET-1 mRNA was detected in the tissues except for heart and liver. It was speculated that ET could play an important role in physiological events in most of the organs.

【 授权许可】

Unknown