Anti-Erythrocyte Membrane Antibodies Detected in Sera of Dogs Naturally Infected with Babesia gibsoni

Journal of Veterinary Medical Science

Takamasa SHIMIZU¹  Susumu MAKIMURA¹  Kozo ADACHI¹  Takashi HASEGAWA¹  Yoshitaka GOTO¹  Akemi YOSHIMOTO¹ 

关键词: anti-erythrocyte membrane antibody;    Babesia gibsoni;    dog;    ELISA;    immunoblotting;   

DOI  :  10.1292/jvms.54.1081

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

References(17)Cited-By(18)Due to the potential for anti-erythrocyte membrane antibodies as possible enhancers of erythrocyte destruction, the presence of serum anti-erythrocyte membrane antibodies in 31 dogs with Babesia gibsoni infection admitted to a veterinary hospital was investigated by an enzyme linked immunosorbent assay (ELISA) and immunoblotting analyses. This infection resulted in an increase of anti-erythrocyte membrane antibodies in 84% (IgG) and 74% (IgM) of 31 infected dogs, respectively. This was confirmed by the similarity in the protein profiles of the erythrocyte membrane antigens immunoblotted with rabbit antiserum to dog erythrocyte membrane antigens and infected dog serum. These results suggest the production of anti-erythrocyte membrane antibodies was induced by B. gibsoni infection.

【 授权许可】

Unknown