Characteristics of Central Nervous System Tuberculosis in a Low-Incidence Country: a Series of 20 Cases and a Review of the Literature

Japanese Journal of Infectious Diseases

Bendayan Daniele¹ 

[1] Pulmonary and Tuberculosis Department, Shmuel Harofe Hospital

关键词: CNS tuberculosis;    HIV;    Israel;   

DOI  :  10.7883/yoken.67.50

学科分类：传染病学

来源: National Institute of Infectious Diseases

【 摘 要 】

References(27)Cited-By(2)Central nervous system tuberculosis (CNS-TB) is a devastating manifestation of tuberculosis (TB) caused by the hematogenous spread of Mycobacterium tuberculosis. Here, I present a retrospective analysis of 20 CNS-TB cases in Israel, a country with a low incidence of TB over an 11-year period (2000–2010). Most of the cases were those of African migrants, with an increased prevalence in adult females and in those with HIV coinfections. Clinical manifestations were usually non-specific, and miliary infiltrates were rare. Lymphocytic meningitis was frequent with bacteriological confirmation in 50% of the cases. The yields of cerebrospinal fluid smear examinations were low (20%). Brain computed tomography revealed tuberculomas (45%) and hydrocephalus (15%). All patients received individual treatment on the basis of drug susceptibility patterns and adjunctive steroid therapy. However, 35% of the patients died within the first year and the mortality rate was strongly correlated to disease severity (90%), HIV coinfection (85%), and hydrocephalus (66%). Progress in new diagnostic tests and early treatment may improve the current high mortality and morbidity rates.

【 授权许可】

Unknown