ATP- and Adenosine-Mediated Signaling in the Central Nervous System: Purinergic Receptor Complex: Generating Adenine Nucleotide-Sensitive Adenosine Receptors

Journal of Pharmacological Sciences

Kazuaki Yoshioka¹  Hiroyasu Nakata¹ 

[1] Department of Molecular Cell Signaling, Tokyo Metropolitan Institute for Neuroscience

关键词: oligomerization;    purinergic receptor;    bioluminescence resonance energy transfer system (BRET);    immunoprecipitation;    G protein-coupled receptor;   

DOI  :  10.1254/jphs.94.88

学科分类：药学

来源: Nihon Yakuri Gakkai Henshuubu / Japanese Pharmacological Society

【 摘 要 】

References(24)Cited-By(15)Adenosine A1 receptors (A1R) are able to form a heteromeric complex with P2Y1 receptors (P2Y1R) that generates A1R with P2Y1R-like agonistic pharmacology. A potent P2Y1R agonist, adenosine 5'-O-(2-thiotriphosphate), binds the A1R binding pocket of the A1R/P2Y1R complex and inhibits adenylyl cyclase activity via Gi/o protein. These mechanisms might be used to fine-tune purinergic inhibition locally at sites where there is a particular oligomerization structure between purinergic receptors and explain the undefined purinergic functions by adenosine and adenine nucleotides.

【 授权许可】

Unknown