Childhood Thyroid Cancer: Comparison of Japan and Belarus

Endocrine Journal

KANJI KUMA⁵  TAKASHI MIMURA³  MASAHIRO ITO²  SHUJI FUKATA⁵  HIROYUKI NAMBA⁴  TOMOKO MOTOMURA¹  ICHIRO SEKINE²  TAMOTSU YOKOZAWA⁵  KIYOTO ASHIZAWA¹  KUNIHIKO ITO³  NAOKATA YOKOYAMA¹  NAOFUMI ISHIKAWA³  YUTAKA SHIRAHIGE¹  SHIGENOBU NAGATAKI¹  SHUNICHI YAMASHITA⁴ 

[1]First Department of Internal Medicine, Atomic Bomb Disease Institute, Nagasaki University School of Medicine

[2]Departments of Molecular Pathology, Atomic Bomb Disease Institute, Nagasaki University School of Medicine

[3]Ito Hospital

[4]Departments of Nature Medicine, Atomic Bomb Disease Institute, Nagasaki University School of Medicine

[5]Kuma Hospital

关键词: Chernobyl;    Japan;    Radiation;    Thyroid neoplasms;    Children;   

DOI  :  10.1507/endocrj.45.203

学科分类：内分泌与代谢学

来源: Japan Endocrine Society

【 摘 要 】

References(30)Cited-By(7)The high incidence of childhood thyroid cancer in Belarus is suspected to be due to radiation exposure after the Chernobyl reactor accident. To clarify the clinical and histological characteristics of childhood thyroid cancer in Belarus, we therefore compared these patients to a radiation non-exposed control series in Japan. In Belarus, 26 thyroid cancers in subjects aged 15 or younger were diagnosed among 25, 000 screened between 1991 and 1995 by Chernobyl-Sasakawa Health and Medical Cooperation Project. The clinical and morphologic features of these 26 cases were compared to 37 childhood thyroid cancers in Japan diagnosed between 1962 and 1995. The age distribution at operation in Belarus showed a peak at 10 years old, with a subsequent fall in numbers. In contrast, the age distribution at operation in Japan showed a smooth increase between the ages of 8 and 14. The mean tumor diameter was smaller in Belarus than that in Japan (1.4±0.7 vs. 4.1±1.7cm, P<0.001). The sex ratio, regional lymph node metastasis, extension to surrounding tissues or lung metastasis did not differ significantly. Histologically, all cases in Belarus were papillary and in Japan 33 cases were papillary and 4 cases were follicular carcinomas. Among papillary carcinomas, the frequency of a solid growth pattern, a criteria for classifying a tumor as poorly differentiated, was higher in Belarus than that in Japan (61.5 vs.18.2%, P<0.001). The difference between the features of childhood thyroid cancer in Japan and Belarus may be due to the difference in the process of carcinogenesis, but more direct evidence and further analysis by molecular epidemiology are needed in Belarussian cases.

【 授权许可】

Unknown