Sustained Analgesic Effect of the Rho Kinase Inhibitor AS1892802 in Rat Models of Chronic Pain

Journal of Pharmacological Sciences

Eiji Yoshimi²  Yasuaki Shimizu²  Nobuaki Takeshita²  Yasuhisa Furuichi¹  Hiroko Yamamoto² 

[1] Applied Pharmacology Research Laboratories, Astellas Pharma, Inc., Japan;Pharmacology Research Laboratories, Astellas Pharma, Inc., Japan

关键词: Rho kinase;    monoiodoacetate-induced arthritis;    streptozotocin-induced neuropathy;   

DOI  :  10.1254/jphs.10158SC

学科分类：药学

来源: Nihon Yakuri Gakkai Henshuubu / Japanese Pharmacological Society

【 摘 要 】

References(15)Cited-By(6)To assess the pharmacological profile of AS1892802, a novel and selective Rho kinase (ROCK) inhibitor, we examined the effects of repeated dosing with AS1892802 on models of monoiodoacetate-induced arthritis and streptozotocin-induced neuropathy. Although single dosing of AS1892802 exerted a short-acting, moderate analgesic effect, repeated dosing exhibited a long-lasting and more potent analgesic effect in both models. Furthermore, the analgesic effect was sustained for seven days after the last administration. These results suggest that peripheral ROCK plays a crucial role in chronic pain maintenance and that AS1892802 may be useful in treating chronic pain.

【 授权许可】

Unknown