Repeated Pre-treatment With Antihistamines Causes Transcriptional Up-regulations of Histamine H1 Receptor and Interleukin-4 Genes in Toluene-2,4-diisocyanate–Sensitized Rats

Journal of Pharmacological Sciences

Noriaki Takeda¹  Hiroyuki Fukui²  Wakana Kuroda¹  Hiroyuki Mizuguchi²  Masaya Hatano²  Chiyo Matsushita²  Hayato Umehara²  Yoshiyuki Kitamura¹ 

[1] Department of Otolaryngology, Institute of Health-Biosciences, The University of Tokushima Graduate School, Japan;Department of Molecular Pharmacology, Institute of Health-Biosciences, The University of Tokushima Graduate School, Japan

关键词: antihistamines;    histamine H1 receptor;    interleukin-4;    nasal allergy;    pre-seasonal prophylactic treatment;   

DOI  :  10.1254/jphs.08222FP

学科分类：药学

来源: Nihon Yakuri Gakkai Henshuubu / Japanese Pharmacological Society

【 摘 要 】

References(34)Cited-By(21)Antihistamines are effective for treatment of seasonal nasal allergy. Recently, prophylactic treatment with antihistamines in patients with pollinosis was reported to be more effective when started before the pollen season. The administration with antihistamines from 2 to 6 weeks before onset of the pollen season is recommended for management of allergic rhinitis in Japan. To determine the reason for the effectiveness of prophylactic treatment with antihistamines, the effects of repeated pre-treatment with antihistamines before provocation with toluene 2,4-diisocyanate (TDI) on their nasal allergy–like behavior and up-regulations of histamine H1 receptors (H1R) and interleukin (IL)-4 mRNAs in their nasal mucosa were examined. Provocation with TDI induced sneezing and up-regulations of H1R and IL-4 mRNAs in the nasal mucosa of TDI-sensitized rats. Repeated pre-treatments with antihistamines including epinastine, olopatadine, or d-chlorpheniramine for 1 to 5 weeks before provocation with TDI suppressed TDI-induced sneezing and the up-regulations of H1R and IL-4 mRNAs in the nasal mucosa more than their administrations once or for 3 days before TDI provocation. Our data indicate that repeated pre-treatment with antihistamines before provocation with TDI is more effective than their single treatment in reducing nasal allergy–like behavior by causing additional suppression of up-regulations of H1R and IL-4 mRNAs in the nasal mucosa.

【 授权许可】

Unknown