Mice are Not Susceptible to Hepatitis E Virus Infection

Journal of Veterinary Medical Science

Naokazu TAKEDA²  Yuriko SUZAKI³  Tian-Cheng LI²  Hiroshi TSUNEMITSU¹  Tatsuo MIYAMURA²  Yasushi AMI³ 

[1] Research Team for Viral Diseases, National Institute of Animal Health;Department of Virology II, National Institute of Infectious Diseases;Division of Experimental Animals Research, National Institute of Infectious Diseases

关键词: C57BL/6;    hepatitis E;    hepatitis E virus;    HEV;    mouse;   

DOI  :  10.1292/jvms.70.1359

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

References(30)Cited-By(13)To determine whether or not mice are susceptible to hepatitis E virus (HEV) infection, C57BL/6 mice were experimentally infected with genotypes 1, 3 and 4 HEV by intravenous injection. Serum and stool samples were collected and used to detect HEV RNA and anti-HEV antibodies by RT-PCR and ELISA. The virus infection was monitored up to two months after inoculation; however, none of the serum or stool samples was positive for virus replication, demonstrating that C57BL/6 mice were not susceptible to HEV.

【 授权许可】

Unknown